Refine Naturals™

Benefits of MIND PROBIOTIC Add-on therapy to antidepressants

In this blog, we will discuss the use and impact of our 2-in-1 probiotic in depression therapy.

Depression is multifactorial, and unique to each person. Accordingly, the same type of treatment may not be optimal for everyone: there may be resistance to treatment, medication not working as well, other underlying health conditions, and increased stress levels [1]. Thus, many people may seek to augment their medications to support and boost their health and well being.



Depression affects the whole body, including sleeping, digestion, higher levels of stress. Many people are treated with antidepressants, in addition to psychotherapy, changes to diet and lifestyle. Gut bacteria play an important role in brain function, as well as mental health conditions, including depression.  There is evidence that shows that patients with major depressive disorder may have lower counts of beneficial bacteria, Bifidobacterium and Lactobacillus, compared to controls [2].

Bifidobacterium and Lactobacillus, in particular, have a positive effect on stress responses and depression symptoms [2].  A review and large analysis of several clinical trials demonstrated that probiotics are effective at reducing depressive symptoms when administered in addition to antidepressants [1].

Mind Probiotic

With this in mind, at Refine Naturals, we have formulated a product, MIND PROBIOTIC, containing Lactobacillus helveticus and Bifidobacterium longum, for both brain and gut health, with proven evidence of:

  • beneficial effects on anxiety and depressive measures [3]
  • promoted healthy mood [4]
  • reduced levels of the stress hormone, cortisol [5]
  • improved sleep quality [6]
  • decrease in gastrointestinal-related stress symptoms [7]

MIND PROBIOTIC, specifically containing beneficial bacteria, Lactobacillus helveticus and Bifidobacterium longum were effective in reducing depressive symptoms when used in addition to antidepressants [3].


At Refine Naturals, we realize that not all natural health supplements are created equal. We concentrate our expertise in choosing quality and evidence backed medicinal as well as non-medicinal ingredients. We keep our labels and marketing practices compliant to advertising standards, so as to never mislead consumers in their decision making. For a complete list of our supplements, click here.

At Refine Naturals: We believe “You Deserve Better than FINE!